| 000 | 02302 am a22002653u 4500 | ||
|---|---|---|---|
| 042 | _adc | ||
| 100 | 1 | 0 |
_aGeng, Fengji _eauthor _9742 |
| 700 | 1 | 0 |
_aMai, Xiaoqin _eauthor _9743 |
| 700 | 1 | 0 |
_aZhan, Jianying _eauthor _9744 |
| 700 | 1 | 0 |
_aXu, Lin _eauthor _9745 |
| 700 | 1 | 0 |
_aGeorgieff, Michael _eauthor _9746 |
| 700 | 1 | 0 |
_aShao, Jie _eauthor _9747 |
| 700 | 1 | 0 |
_aLozoff, Betsy _eauthor _9748 |
| 245 | 0 | 0 | _aTiming of iron deficiency and recognition memory in infancy |
| 260 | _c2022-01. | ||
| 500 | _a/pmc/articles/PMC7338245/ | ||
| 500 | _a/pubmed/31906824 | ||
| 520 | _aOBJECTIVE: To determine the relationship between iron deficiency (or iron-deficient, ID) and neural correlates of recognition memory depending on ID timing (gestation vs. infancy) and infant age at testing (9 vs. 18 months). STUDY DESIGN: Event-related potentials (ERP) were used in a visual recognition memory task (mother vs. stranger face) to compare healthy term infants according to iron status at birth and 9 months. Fetal-neonatal ID was defined as cord serum ferritin < 75 μg/l or zinc protoporphrin/heme ratio > 118 μmol/mol, postnatal ID as ≥ 2 abnormal iron measures at 9 months with normal cord-blood iron status, and iron-sufficient as not ID at birth or 9 months. Recognition of mother faces was measured by negative component (Nc) and late slow wave (LSW). These ERP components reflect attention and memory updating processes, respectively. RESULTS: All groups showed differences in Nc amplitude elicited by mother and stranger faces at 9 months. At 18 months, only postnatal ID and iron-sufficient groups showed condition differences in Nc amplitude. However, the 2 groups were different in the involved brain regions. For LSW, only the 2 ID groups showed condition differences in amplitude at 9 months. At 18 months, condition differences were not observed in any group. CONCLUSIONS: This study indicates that the timing of ID in early life (fetal-neonatal vs. postnatal) modulates the impact of ID on recognition memory. Such impact also varies depending on the age of infants at testing (9 vs. 18 months). | ||
| 540 | _a | ||
| 546 | _aen | ||
| 690 | _aArticle | ||
| 655 | 7 |
_aText _2local |
|
| 786 | 0 | _nNutr Neurosci | |
| 856 | 4 | 1 |
_uhttp://dx.doi.org/10.1080/1028415X.2019.1704991 _zConnect to this object online. |
| 999 |
_c1333 _d1333 |
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