000			02801 am a22002773u 4500
042			_adc
100	1	0	_aGustafson, Kathleen M. _eauthor _9777
700	1	0	_aLiao, Ke _eauthor _9778
700	1	0	_aMathis, Nicole B. _eauthor _9779
700	1	0	_aShaddy, D. Jill _eauthor _9780
700	1	0	_aKerling, Elizabeth H. _eauthor _9781
700	1	0	_aChristifano, Danielle N. _eauthor _9782
700	1	0	_aColombo, John _eauthor _9783
700	1	0	_aCarlson, Susan E. _eauthor _9784
245	0	0	_aPrenatal docosahexaenoic acid supplementation has long-term effects on childhood behavioral and brain responses during performance on an inhibitory task
260			_c2022-01.
500			_a/pmc/articles/PMC7369249/
500			_a/pubmed/31957558
520			_aINTRODUCTION: Offspring from a prenatal docosahexaenoic acid (DHA) supplementation trial, in which pregnant women were assigned to placebo or 600mg DHA/day, were followed to determine the effect of prenatal DHA supplementation on children's behavior and brain function at 5.5 years (n=81 placebo, n=86 supplemented). METHODS: Event-related potentials (ERP) were recorded during a visual task requiring a button press (Go) to frequent target stimuli and response inhibition to the rare stimuli (No-Go). Univariate ANOVAs were used to test differences between group and sex for each behavioral measure. A three-way mixed-design multivariate analysis of variance (MANOVA) was used to examine statistical ERP differences. RESULTS: There was a significant sex × group interaction for hit rate and errors of omission; there was no difference between males and females in the placebo group, but DHA males were significantly better than DHA females For false alarms (failure to inhibit), males overall, and the placebo group made more false alarms while DHA females made significantly fewer than placebo females and DHA males. ERP P2 amplitude was larger in the DHA group. There was a significant ERP N2 amplitude condition effect observed in females and DHA group males, however, placebo group males did not generate this typical ERP condition difference. DISCUSSION: Prenatal DHA supplementation improved inhibitory performance overall, especially for females in the DHA group, possibly accounting for their conservative behavior during Go trials. Development of brain regions responsible for visual processing may be sensitive to maternal DHA status, evidenced by greater P2 amplitude in children whose mothers received DHA. Males may benefit more from maternal DHA supplementation, indicated by the N2 condition effect seen only in males in the DHA group.
540			_a
546			_aen
690			_aArticle
655	7		_aText _2local
786	0		_nNutr Neurosci
856	4	1	_uhttp://dx.doi.org/10.1080/1028415X.2020.1712535 _zConnect to this object online.
999			_c1354 _d1354