000 02265 am a22002293u 4500
042 _adc
100 1 0 _aBarnes, Cherie N.
_eauthor
_9749
700 1 0 _aWallace, Conner W.
_eauthor
_9750
700 1 0 _aJacobowitz, Brielle S.
_eauthor
_9751
700 1 0 _aFordahl, Steve C
_eauthor
_9752
245 0 0 _aReduced Phasic Dopamine Release and Slowed Dopamine Uptake Occur in the Nucleus Accumbens after a Diet High in Saturated but not Unsaturated Fat.
260 _c2022-01.
500 _a/pmc/articles/PMC7343597/
500 _a/pubmed/31914869
520 _aHigh-fat diets are linked with obesity and changes in dopamine neurotransmission. Mounting evidence shows that saturated fat impacts dopamine neurons and their terminal fields, but little is known about the effect a diet high in unsaturated fat has on the dopamine system. This study sought to determine whether fat type, saturated vs. unsaturated, differentially affected body weight, blood glucose regulation, locomotor behavior, and control of dopamine release and uptake at dopamine neuron terminals in the nucleus accumbens (NAc). C57BL/6 mice were fed a control diet or a nutrient-matched diet high in saturated fat (SF), unsaturated flaxseed oil (Flax) or a blend of the two fats. After 6-weeks, mice from each high-fat diet group gained significantly more weight than Controls, but the group fed Flax gained less weight than the SF group and had fasting blood glucose levels similar to Controls. Ex-vivo fast scan cyclic voltammetry revealed the SF group also had significantly slower synaptic dopamine clearance and a reduced capacity for phasic dopamine release in the nucleus accumbens (NAc), but the Flax and Blend groups resembled Controls. These data show that different types of dietary fat have substantially different effects on metabolic phenotype and influence how dopamine terminals in the NAc regulate dopamine neurotransmission. Our data also suggests that a diet high in unsaturated fat may preserve normal metabolic and behavioral parameters as well as dopamine signaling in the NAc.
540 _a
546 _aen
690 _aArticle
655 7 _aText
_2local
786 0 _nNutr Neurosci
856 4 1 _uhttp://dx.doi.org/10.1080/1028415X.2019.1707421
_zConnect to this object online.
999 _c1593
_d1593