| 000 | 02488 am a22002293u 4500 | ||
|---|---|---|---|
| 042 | _adc | ||
| 100 | 1 | 0 |
_aMutz, Julian _eauthor _91318 |
| 700 | 1 | 0 |
_aHoppen, Thole H. _eauthor _91319 |
| 700 | 1 | 0 |
_aFabbri, Chiara _eauthor _91320 |
| 700 | 1 | 0 |
_aLewis, Cathryn M. _eauthor _91321 |
| 245 | 0 | 0 | _aAnxiety disorders and age-related changes in physiology |
| 260 | _c2022-09. | ||
| 500 | _a/pmc/articles/PMC7613411/ | ||
| 500 | _a/pubmed/35048844 | ||
| 520 | _aBACKGROUND: Anxiety disorders are leading contributors to the global disease burden, highly prevalent across the lifespan, and associated with substantially increased morbidity and early mortality. AIMS: The aim of this study was to examine age-related changes across a wide range of physiological measures in middle-aged and older adults with a lifetime history of anxiety disorders compared to healthy controls. METHOD: The UK Biobank study recruited >500,000 adults, aged 37-73, between 2006-2010. We used generalised additive models to estimate non-linear associations between age and hand-grip strength, cardiovascular function, body composition, lung function and heel bone mineral density in cases and in controls. RESULTS: The main dataset included 332,078 adults (mean age = 56.37 years; 52.65% females). In both sexes, individuals with anxiety disorders had a lower hand-grip strength and blood pressure, while their pulse rate and body composition measures were higher than in healthy controls. Case-control differences were larger when considering individuals with chronic and/or severe anxiety disorders, and differences in body composition were modulated by depression comorbidity status. Differences in age-related physiological changes between female anxiety disorder cases and healthy controls were most evident for blood pressure, pulse rate and body composition, while in males for hand-grip strength, blood pressure and body composition. Most differences in physiological measures between cases and controls decreased with increasing age. CONCLUSIONS: Individuals with a lifetime history of anxiety disorders differed from healthy controls across multiple physiological measures, with some evidence of case-control differences by age. The differences observed varied by chronicity/severity and depression comorbidity. | ||
| 540 | _a | ||
| 546 | _aen | ||
| 690 | _aArticle | ||
| 655 | 7 |
_aText _2local |
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| 786 | 0 | _nBr J Psychiatry | |
| 856 | 4 | 1 |
_uhttp://dx.doi.org/10.1192/bjp.2021.189 _zConnect to this object online. |
| 999 |
_c1644 _d1644 |
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