000 01682 am a22002413u 4500
042 _adc
100 1 0 _aRichard, Arianne C.
_eauthor
_91043
700 1 0 _aFrazer, Gordon L.
_eauthor
_91044
700 1 0 _aMa, Claire Y.
_eauthor
_91045
700 1 0 _aGriffiths, Gillian M
_eauthor
_91046
245 0 0 _aStaggered starts in the race to T cell activation
260 _c2021-11-01.
500 _a/pmc/articles/PMC7612485/
500 _a/pubmed/34649777
520 _aHow T lymphocytes tune their responses to different strengths of stimulation is a fundamental question in immunology. Recent work using new optogenetic, single-cell genomic and live-imaging approaches has revealed that stimulation strength controls the rate of individual cell responses within a population. Moreover, these responses have been found to use shared molecular programs, regardless of stimulation strength. However, additional data indicate that stimulation duration or cytokine feedback can impact later gene expression phenotypes of activated cells. In-depth molecular studies have suggested mechanisms by which stimulation strength might modulate the probability of T cell activation. This emerging model allows activating T cells to achieve a wide range of population responses through probabilistic control within individual cells.
540 _a
540 _ahttps://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license.
546 _aen
690 _aArticle
655 7 _aText
_2local
786 0 _nTrends Immunol
856 4 1 _uhttp://dx.doi.org/10.1016/j.it.2021.09.004
_zConnect to this object online.
999 _c1706
_d1706