000			01682 am a22002413u 4500
042			_adc
100	1	0	_aRichard, Arianne C. _eauthor _91043
700	1	0	_aFrazer, Gordon L. _eauthor _91044
700	1	0	_aMa, Claire Y. _eauthor _91045
700	1	0	_aGriffiths, Gillian M _eauthor _91046
245	0	0	_aStaggered starts in the race to T cell activation
260			_c2021-11-01.
500			_a/pmc/articles/PMC7612485/
500			_a/pubmed/34649777
520			_aHow T lymphocytes tune their responses to different strengths of stimulation is a fundamental question in immunology. Recent work using new optogenetic, single-cell genomic and live-imaging approaches has revealed that stimulation strength controls the rate of individual cell responses within a population. Moreover, these responses have been found to use shared molecular programs, regardless of stimulation strength. However, additional data indicate that stimulation duration or cytokine feedback can impact later gene expression phenotypes of activated cells. In-depth molecular studies have suggested mechanisms by which stimulation strength might modulate the probability of T cell activation. This emerging model allows activating T cells to achieve a wide range of population responses through probabilistic control within individual cells.
540			_a
540			_ahttps://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license.
546			_aen
690			_aArticle
655	7		_aText _2local
786	0		_nTrends Immunol
856	4	1	_uhttp://dx.doi.org/10.1016/j.it.2021.09.004 _zConnect to this object online.
999			_c1706 _d1706