000			03990 am a22004933u 4500
042			_adc
100	1	0	_aOng, Yi Ying _eauthor _91128
700	1	0	_aPang, Wei Wei _eauthor _91129
700	1	0	_aHuang, Jonathan Y. _eauthor _91130
700	1	0	_aAris, Izzuddin M. _eauthor _91131
700	1	0	_aSadananthan, Suresh Anand _eauthor _91132
700	1	0	_aTint, Mya-Thway _eauthor _91133
700	1	0	_aYuan, Wen Lun _eauthor _91134
700	1	0	_aChen, Ling-Wei _eauthor _91135
700	1	0	_aChan, Yiong Huak _eauthor _91136
700	1	0	_aKarnani, Neerja _eauthor _91137
700	1	0	_aVelan, S. Sendhil _eauthor _91138
700	1	0	_aFortier, Marielle V. _eauthor _91139
700	1	0	_aChoo, Jonathan _eauthor _91140
700	1	0	_aLing, Lieng Hsi _eauthor _91141
700	1	0	_aShek, Lynette _eauthor _91142
700	1	0	_aTan, Kok Hian _eauthor _91143
700	1	0	_aGluckman, Peter D. _eauthor _91144
700	1	0	_aYap, Fabian _eauthor _91145
700	1	0	_aChong, Yap-Seng _eauthor _91146
700	1	0	_aGodfrey, Keith M. _eauthor _91147
700	1	0	_aChong, Mary F-F. _eauthor _91148
700	1	0	_aChan, Shiao-Yng _eauthor _91149
700	1	0	_aEriksson, Johan G. _eauthor _91150
700	1	0	_aWlodek, Mary E. _eauthor _91151
700	1	0	_aLee, Yung Seng _eauthor _91152
700	1	0	_aMichael, Navin _eauthor _91153
245	0	0	_aBreastfeeding may benefit cardiometabolic health of children exposed to increased gestational glycemia in utero
260			_c2022-08.
500			_a/pmc/articles/PMC7613060/
500			_a/pubmed/35124728
520			_aPURPOSE: There is altered breastmilk composition among mothers with gestational diabetes and conflicting evidence on whether breastfeeding is beneficial or detrimental to their offspring's cardiometabolic health. We aimed to investigate associations between breastfeeding and offspring's cardiometabolic health across the range of gestational glycemia. METHODS: We included 827 naturally-conceived, term singletons from a prospective mother-child cohort. We measured gestational (26-28weeks) fasting plasma glucose (FPG) and 2-hour plasma glucose (2hrPG) after an oral glucose tolerance test as continuous variables. Participants were classified into 2 breastfeeding categories (high/intermediate vs. low) according to their breastfeeding duration and exclusivity. Main outcome measures included magnetic resonance imaging (MRI)-measured abdominal fat, intramyocellular lipids (IMCL), and liver fat, quantitative magnetic resonance (QMR)-measured body fat mass, blood pressure, blood lipids, and insulin resistance at 6 years old (all continuous variables). We evaluated if gestational glycemia (FPG & 2hrPG) modified the association of breastfeeding with offspring outcomes after adjusting for confounders using a multiple linear regression model that included a 'gestational glycemia x breastfeeding' interaction term. RESULTS: With increasing gestational FPG, high/intermediate (vs. low) breastfeeding was associated with lower levels of IMCL (p-interaction=0.047), liver fat (p-interaction=0.033), and triglycerides (p-interaction=0.007), after adjusting for confounders. Specifically, at 2 standard deviations above the mean gestational FPG level, high/intermediate (vs. low) breastfeeding was linked to lower adjusted mean IMCL (0.39% of water signal [0.29,0.50] vs. 0.54% of water signal [0.46,0.62]), liver fat (0.39% by weight [0.20,0.58] vs. 0.72% by weight [0.59,0.85]), and triglycerides (0.62mmol/L [0.51,0.72] vs. 0.86mmol/L [0.75,0.97]). 2hrPG did not significantly modify the association between breastfeeding and childhood cardiometabolic risk. CONCLUSION: Our findings suggest breastfeeding may confer protection against adverse fat partitioning and higher triglyceride concentration among children exposed to increased glycemia in utero.
540			_a
546			_aen
690			_aArticle
655	7		_aText _2local
786	0		_nEur J Nutr
856	4	1	_uhttp://dx.doi.org/10.1007/s00394-022-02800-7 _zConnect to this object online.
999			_c1731 _d1731