| 000 | 02352 am a22002773u 4500 | ||
|---|---|---|---|
| 042 | _adc | ||
| 100 | 1 | 0 |
_aKlein-Flügge, Miriam C _eauthor _91757 |
| 700 | 1 | 0 |
_aJensen, Daria EA _eauthor _91758 |
| 700 | 1 | 0 |
_aTakagi, Yu _eauthor _91759 |
| 700 | 1 | 0 |
_aPriestley, Luke _eauthor _91760 |
| 700 | 1 | 0 |
_aVerhagen, Lennart _eauthor _91761 |
| 700 | 1 | 0 |
_aSmith, Stephen M _eauthor _91762 |
| 700 | 1 | 0 |
_aRushworth, Matthew FS _eauthor _91763 |
| 245 | 0 | 0 | _aRelationship between nuclei-specific amygdala connectivity and mental health dimensions in humans |
| 260 | _c2022-12. | ||
| 500 | _a/pmc/articles/PMC7613949/ | ||
| 500 | _a/pubmed/36138220 | ||
| 520 | _aThere has been increasing interest in using neuroimaging measures to predict psychiatric disorders. However, predictions usually rely on large brain networks and large disorder heterogeneity. Thus, they lack both anatomical and behavioural specificity, preventing the advancement of targeted interventions. Here, we address both challenges. First, using resting-state functional MRI, we parcellated the amygdala, a region implicated in mood disorders, into seven nuclei. Next, a questionnaire factor analysis provided subclinical mental health dimensions frequently altered in anxious-depressive individuals, such as negative emotions and sleep problems. Finally, for each behavioural dimension, we identified the most predictive resting-state functional connectivity between individual amygdala nuclei and highly specific regions of interest such as the dorsal raphe nucleus in the brainstem or medial frontal cortical regions. Connectivity in circumscribed amygdala networks predicted behaviours in an independent dataset. Our results reveal specific relations between mental health dimensions and connectivity in precise subcortical networks. | ||
| 540 | _a | ||
| 540 | _ahttps://www.springernature.com/gp/open-research/policies/accepted-manuscript-termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms | ||
| 546 | _aen | ||
| 690 | _aArticle | ||
| 655 | 7 |
_aText _2local |
|
| 786 | 0 | _nNat Hum Behav | |
| 856 | 4 | 1 |
_uhttp://dx.doi.org/10.1038/s41562-022-01434-3 _zConnect to this object online. |
| 999 |
_c1760 _d1760 |
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