000			02010 am a22002173u 4500
042			_adc
100	1	0	_aPizzuto, Malvina _eauthor _91336
700	1	0	_aPelegrin, Pablo _eauthor _91337
700	1	0	_aRuysschaert, Jean-Marie _eauthor _91338
245	0	0	_aLipid-protein interactions regulating the canonical and the non-canonical NLRP3 inflammasome
260			_c2022-07-01.
500			_a/pmc/articles/PMC7613582/
500			_a/pubmed/35901922
520			_aThe inflammatory response is a complex regulated effector mechanism of the innate immune system that is initiated after tissue injury or infection. The NLRP3 inflammasome is an important initiator of inflammation by regulating the activation of caspase-1, the maturation of pro-inflammatory cytokines and the induction of pyroptotic cell death. Numerous studies demonstrate that the NLRP3 inflammasome could be modulated by lipids, existing a relation between lipids and the activation of different inflammatory processes. In this review we will summarize how the mechanism of NLRP3 inflammasome activation is regulated by different lipids and how these lipids control specific cellular localization of NLRP3 during activation. Although being a cytosolic protein, NLRP3 interacts with lipids accessible in neighbor membranes. Also, the modulation of NLRP3 by endogenous lipids has been found causative of different metabolic diseases and bacterial-pathogenic lipids lead to NLRP3 activation during infection. The understanding of the modulation of the NLRP3 inflammasome by lipids has resulted not only in a better knowledge about the mechanism of NLRP3 activation and its implication in disease, but also opens a new avenue for the development of novel therapeutics and vaccines, as NLRP3 could be modulated by synthetic lipids used as adjuvants.
540			_a
546			_aen
690			_aArticle
655	7		_aText _2local
786	0		_nProg Lipid Res
856	4	1	_uhttp://dx.doi.org/10.1016/j.plipres.2022.101182 _zConnect to this object online.
999			_c1779 _d1779