000 02411 am a22003013u 4500
042 _adc
100 1 0 _aSkou, Søren T.
_eauthor
_91322
700 1 0 _aMair, Frances S
_eauthor
_91323
700 1 0 _aFortin, Martin
_eauthor
_91324
700 1 0 _aGuthrie, Bruce
_eauthor
_91325
700 1 0 _aNunes, Bruno P.
_eauthor
_91326
700 1 0 _aMiranda, J. Jaime
_eauthor
_91327
700 1 0 _aBoyd, Cynthia
_eauthor
_91328
700 1 0 _aPati, Sanghamitra
_eauthor
_91329
700 1 0 _aMtenga, Sally
_eauthor
_91330
700 1 0 _aSmith, Susan M.
_eauthor
_91331
245 0 0 _aMultimorbidity
260 _c2022-07-14.
500 _a/pmc/articles/PMC7613517/
500 _a/pubmed/35835758
520 _aMultimorbidity (≥2 co-existing conditions in an individual) is a growing global challenge with substantial impact on individuals, carers and society. It occurs a decade earlier in socioeconomically deprived communities, is associated with premature death, poorer function and quality of life, and increased health care utilization. Mechanisms underlying the development of multimorbidity are complex, interrelated and multilevel, but can be considered related to aging and underlying biological mechanisms and to broader determinants of health, e.g. socioeconomic deprivation. Little is known about prevention, but focusing on psychosocial and behavioral factors, particularly population level interventions and structural changes, is likely to be beneficial. Most clinical practice guidelines and healthcare training and delivery focuses on single diseases, leading to care that is sometimes inadequate and potentially harmful. Multimorbidity requires person-centered care, prioritizing what matters most to the individual and their carers, ensuring care that is effectively coordinated and minimally disruptive, and aligns with patient values. Interventions are likely to be complex and multifaceted. While an increasing number of studies examining multimorbidity interventions are available, there is still limited evidence to support any approach. Greater investment in multimorbidity research and training along with reconfiguration of healthcare supporting management of multimorbidity is urgently needed.
540 _a
546 _aen
690 _aArticle
655 7 _aText
_2local
786 0 _nNat Rev Dis Primers
856 4 1 _uhttp://dx.doi.org/10.1038/s41572-022-00376-4
_zConnect to this object online.
999 _c1901
_d1901