000 01957 am a22002293u 4500
042 _adc
100 1 0 _aPlomin, Robert
_eauthor
_91819
700 1 0 _aGidziela, Agnieszka
_eauthor
_91820
700 1 0 _aMalanchini, Margherita
_eauthor
_91821
700 1 0 _avon Stumm, Sophie
_eauthor
_91822
245 0 0 _aGene-environment interaction using polygenic scores: Do polygenic scores for psychopathology moderate predictions from environmental risk to behavior problems?
260 _c2022-09-23.
500 _a/pmc/articles/PMC7613991/
500 _a/pubmed/36148872
520 _aThe DNA revolution has energized research on interactions between genes and environments (GxE) by creating indices of G (polygenic scores) that are powerful predictors of behavioral traits. Here, we test the extent to which polygenic scores for ADHD and neuroticism moderate associations between parent reports of their children's environmental risk (E) at ages 3 and 4 and teacher ratings of behavior problems (hyperactivity/inattention, conduct problems, emotional symptoms, and peer relationship problems) at ages 7, 9 and 12. The sampling frame included up to 6687 twins from the Twins Early Development Study (TEDS). Our analyses focused on relative effect sizes of G, E and GxE in predicting behavior problems. G, E and GxE predicted up to 2%, 2% and 0.4%, respectively, of the variance in externalizing behavior problems (hyperactivity/inattention and conduct problems) across ages 7, 9 and 12, with no clear developmental trends. G and E predictions of emotional symptoms and peer relationship problems were weaker. A quarter (12 of 48) of our tests of GxE were nominally significant (p =.05). Increasing the predictive power of G and E would enhance the search for GxE.
540 _a
546 _aen
690 _aArticle
655 7 _aText
_2local
786 0 _nDev Psychopathol
856 4 1 _uhttp://dx.doi.org/10.1017/S0954579422000931
_zConnect to this object online.
999 _c1904
_d1904