000 01501 am a22002533u 4500
042 _adc
100 1 0 _aKhodabukus, Alastair
_eauthor
_92269
700 1 0 _aGuyer, Tyler
_eauthor
_92270
700 1 0 _aMoore, Axel C.
_eauthor
_92271
700 1 0 _aStevens, Molly M.
_eauthor
700 1 0 _aGuldberg, Robert E.
_eauthor
_92273
700 1 0 _aBursac, Nenad
_eauthor
_92274
245 0 0 _aTranslating musculoskeletal bioengineering into tissue regeneration therapies
260 _c2022-10-12.
500 _a/pmc/articles/PMC7614064/
500 _a/pubmed/36223445
520 _aMusculoskeletal injuries and disorders are the leading cause of physical disability worldwide and a considerable socioeconomic burden. The lack of effective therapies has driven the development of novel bioengineering approaches that have recently started to gain clinical approvals. In this review, we first discuss the self-repair capacity of the musculoskeletal tissues and describe causes of musculoskeletal dysfunction. We then review the development of novel biomaterial, immunomodulatory, cellular, and gene therapies to treat musculoskeletal disorders. Lastly, we consider the recent regulatory changes and future areas of technological progress that can accelerate translation of these therapies to clinical practice.
540 _a
546 _aen
690 _aArticle
655 7 _aText
_2local
786 0 _nSci Transl Med
856 4 1 _uhttp://dx.doi.org/10.1126/scitranslmed.abn9074
_zConnect to this object online.
999 _c1906
_d1906