| 000 | 02522 am a22003493u 4500 | ||
|---|---|---|---|
| 042 | _adc | ||
| 100 | 1 | 0 |
_aScheggia, Diego _eauthor _91443 |
| 700 | 1 | 0 |
_aLa Greca, Filippo _eauthor _91444 |
| 700 | 1 | 0 |
_aMaltese, Federica _eauthor _91445 |
| 700 | 1 | 0 |
_aChiacchierini, Giulia _eauthor _91446 |
| 700 | 1 | 0 |
_aItalia, Maria _eauthor _91447 |
| 700 | 1 | 0 |
_aMolent, Cinzia _eauthor _91448 |
| 700 | 1 | 0 |
_aBernardi, Fabrizio _eauthor _91449 |
| 700 | 1 | 0 |
_aCoccia, Giulia _eauthor _91450 |
| 700 | 1 | 0 |
_aCarrano, Niccolò _eauthor _91451 |
| 700 | 1 | 0 |
_aZianni, Elisa _eauthor _91452 |
| 700 | 1 | 0 |
_aGardoni, Fabrizio _eauthor _91453 |
| 700 | 1 | 0 |
_aDiluca, Monica _eauthor _91454 |
| 700 | 1 | 0 |
_aPapaleo, Francesco _eauthor _91455 |
| 245 | 0 | 0 | _aReciprocal cortico-amygdala connections regulate prosocial and selfish choices in mice |
| 260 | _c2022-11. | ||
| 500 | _a/pmc/articles/PMC7613781/ | ||
| 500 | _a/pubmed/36280797 | ||
| 520 | _aDecisions that favor one's own interest versus the interest of another individual depend on context and the relationships between individuals. The neurobiology underlying selfish choices or choices that benefit others is not understood. We developed a two-choice social decision-making task in which mice can decide whether or not to share a reward with their conspecifics. Preference for altruistic choices was modulated by familiarity, sex, social contact, hunger, hierarchical status, and emotional state matching. Fiber photometry recordings and chemogenetic manipulations demonstrated that BLA neurons are involved in the establishment of prosocial decisions. In particular, BLA neurons projecting to the prelimbic region (PL) of the PFC mediated the development of a preference for altruistic choices, whereas PL projections to the BLA modulated self-interest motives on decision-making. This provides a neurobiological model of altruistic and selfish choices with relevance to pathologies associated with dysfunctions in social decision-making. | ||
| 540 | _a | ||
| 540 | _ahttps://www.springernature.com/gp/open-research/policies/accepted-manuscript-termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms | ||
| 546 | _aen | ||
| 690 | _aArticle | ||
| 655 | 7 |
_aText _2local |
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| 786 | 0 | _nNat Neurosci | |
| 856 | 4 | 1 |
_uhttp://dx.doi.org/10.1038/s41593-022-01179-2 _zConnect to this object online. |
| 999 |
_c1947 _d1947 |
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