000 02522 am a22003493u 4500
042 _adc
100 1 0 _aScheggia, Diego
_eauthor
_91443
700 1 0 _aLa Greca, Filippo
_eauthor
_91444
700 1 0 _aMaltese, Federica
_eauthor
_91445
700 1 0 _aChiacchierini, Giulia
_eauthor
_91446
700 1 0 _aItalia, Maria
_eauthor
_91447
700 1 0 _aMolent, Cinzia
_eauthor
_91448
700 1 0 _aBernardi, Fabrizio
_eauthor
_91449
700 1 0 _aCoccia, Giulia
_eauthor
_91450
700 1 0 _aCarrano, Niccolò
_eauthor
_91451
700 1 0 _aZianni, Elisa
_eauthor
_91452
700 1 0 _aGardoni, Fabrizio
_eauthor
_91453
700 1 0 _aDiluca, Monica
_eauthor
_91454
700 1 0 _aPapaleo, Francesco
_eauthor
_91455
245 0 0 _aReciprocal cortico-amygdala connections regulate prosocial and selfish choices in mice
260 _c2022-11.
500 _a/pmc/articles/PMC7613781/
500 _a/pubmed/36280797
520 _aDecisions that favor one's own interest versus the interest of another individual depend on context and the relationships between individuals. The neurobiology underlying selfish choices or choices that benefit others is not understood. We developed a two-choice social decision-making task in which mice can decide whether or not to share a reward with their conspecifics. Preference for altruistic choices was modulated by familiarity, sex, social contact, hunger, hierarchical status, and emotional state matching. Fiber photometry recordings and chemogenetic manipulations demonstrated that BLA neurons are involved in the establishment of prosocial decisions. In particular, BLA neurons projecting to the prelimbic region (PL) of the PFC mediated the development of a preference for altruistic choices, whereas PL projections to the BLA modulated self-interest motives on decision-making. This provides a neurobiological model of altruistic and selfish choices with relevance to pathologies associated with dysfunctions in social decision-making.
540 _a
540 _ahttps://www.springernature.com/gp/open-research/policies/accepted-manuscript-termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms
546 _aen
690 _aArticle
655 7 _aText
_2local
786 0 _nNat Neurosci
856 4 1 _uhttp://dx.doi.org/10.1038/s41593-022-01179-2
_zConnect to this object online.
999 _c1947
_d1947