000			01906 am a22002293u 4500
042			_adc
100	1	0	_aNampoothiri, Sreekala _eauthor _91477
700	1	0	_aNogueiras, Ruben _eauthor _91478
700	1	0	_aSchwaninger, Markus _eauthor _91479
700	1	0	_aPrevot, Vincent _eauthor
245	0	0	_aGlial cells as integrators of peripheral and central signals in the regulation of energy homeostasis
260			_c2022-07-01.
500			_a/pmc/articles/PMC7613794/
500			_a/pubmed/35879459
520			_aCommunication between the periphery and the brain is key for maintaining energy homeostasis. To do so, peripheral signals from the circulation reach the brain via the circumventricular organs (CVOs), which are characterized by fenestrated vessels lacking the protective blood-brain barrier (BBB). Glial cells, by virtue of their plasticity and their ideal location at the interface of blood vessels and neurons, participate in the integration and transmission of peripheral information to neuronal networks within the brain for the neuroendocrine control of whole-body metabolism. Metabolic diseases, such as obesity and type 2 diabetes, can disrupt the brain-to-periphery communication mediated by glial cells, highlighting the relevance of these cell types in the pathophysiology of such complications. An improved understanding of how glial cells integrate and respond to metabolic and humoral signals has become a priority for the discovery of promising therapeutic strategies to treat metabolic disorders. This review highlights the role of glial cells in the exchange of metabolic signals between the periphery and the brain that are relevant for the regulation of whole-body energy homeostasis.
540			_a
546			_aen
690			_aArticle
655	7		_aText _2local
786	0		_nNat Metab
856	4	1	_uhttp://dx.doi.org/10.1038/s42255-022-00610-z _zConnect to this object online.
999			_c1959 _d1959