000 02281 am a22002773u 4500
042 _adc
100 1 0 _aRoy, Srestha
_eauthor
_92423
700 1 0 _aVaippully, Rahul
_eauthor
_92424
700 1 0 _aLokesh, Muruga
_eauthor
_92425
700 1 0 _aNalupurackal, Gokul
_eauthor
_92426
700 1 0 _aEdwina, Privita
_eauthor
_92427
700 1 0 _aBajpai, Saumendra
_eauthor
_92428
700 1 0 _aRoy, Basudev
_eauthor
_92429
245 0 0 _aComparison of translational and rotational modes towards passive rheology of the cytoplasm of MCF-7 cells using optical tweezers
260 _c2023-01-09.
500 _a/pmc/articles/PMC7614090/
500 _a/pubmed/36685106
520 _aA colloidal particle placed inside the cell cytoplasm is enmeshed within a network of cytoskeletal fibres immersed in the cytosolic fluid. The translational mode is believed to yield different rheological parameters than the rotational mode, given that these modes stretch the fibers differently. We compare the parameters for Michigan Cancer Foundation-7 (MCF-7) cells in this manuscript and find that the results are well comparable to each other. At low values of 0 Hz viscosity, the rotational and translational viscoelasticity matches well. However, discrepancies appear at higher values which may indicate that the cytoskeletal modes involved in rotation and translation of the particle are getting invoked. We also show that the 0 Hz viscosity increases as the cell ages under the conditions of constant room temperature of 25(°)C on the sample chamber.
540 _a
540 _ahttps://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and thattheoriginalpublication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
546 _aen
690 _aArticle
655 7 _aText
_2local
786 0 _nFront Phys
856 4 1 _uhttp://dx.doi.org/10.3389/fphy.2022.1099958
_zConnect to this object online.
999 _c1968
_d1968