000 02352 am a22002773u 4500
042 _adc
100 1 0 _aKlein-Flügge, Miriam C
_eauthor
_91757
700 1 0 _aJensen, Daria EA
_eauthor
_91758
700 1 0 _aTakagi, Yu
_eauthor
_91759
700 1 0 _aPriestley, Luke
_eauthor
_91760
700 1 0 _aVerhagen, Lennart
_eauthor
_91761
700 1 0 _aSmith, Stephen M
_eauthor
_91762
700 1 0 _aRushworth, Matthew FS
_eauthor
_91763
245 0 0 _aRelationship between nuclei-specific amygdala connectivity and mental health dimensions in humans
260 _c2022-12.
500 _a/pmc/articles/PMC7613949/
500 _a/pubmed/36138220
520 _aThere has been increasing interest in using neuroimaging measures to predict psychiatric disorders. However, predictions usually rely on large brain networks and large disorder heterogeneity. Thus, they lack both anatomical and behavioural specificity, preventing the advancement of targeted interventions. Here, we address both challenges. First, using resting-state functional MRI, we parcellated the amygdala, a region implicated in mood disorders, into seven nuclei. Next, a questionnaire factor analysis provided subclinical mental health dimensions frequently altered in anxious-depressive individuals, such as negative emotions and sleep problems. Finally, for each behavioural dimension, we identified the most predictive resting-state functional connectivity between individual amygdala nuclei and highly specific regions of interest such as the dorsal raphe nucleus in the brainstem or medial frontal cortical regions. Connectivity in circumscribed amygdala networks predicted behaviours in an independent dataset. Our results reveal specific relations between mental health dimensions and connectivity in precise subcortical networks.
540 _a
540 _ahttps://www.springernature.com/gp/open-research/policies/accepted-manuscript-termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms
546 _aen
690 _aArticle
655 7 _aText
_2local
786 0 _nNat Hum Behav
856 4 1 _uhttp://dx.doi.org/10.1038/s41562-022-01434-3
_zConnect to this object online.
999 _c2035
_d2035