000 02035 am a22002773u 4500
042 _adc
100 1 0 _aBenjamin, Mercilena
_eauthor
_91764
700 1 0 _aMalakar, Pushkar
_eauthor
_91765
700 1 0 _aSinha, Rohit Anthony
_eauthor
_91766
700 1 0 _aNasser, Mohd Wasim
_eauthor
_91767
700 1 0 _aBatra, Surinder K.
_eauthor
_91768
700 1 0 _aSiddiqui, Jawed Akhtar
_eauthor
_91769
700 1 0 _aChakravarti, Bandana
_eauthor
_91770
245 0 0 _aMolecular signaling network and therapeutic developments in breast cancer brain metastasis
260 _c2023-07.
500 _a/pmc/articles/PMC7613958/
500 _a/pubmed/36536947
520 _aBreast cancer (BC) is one of the most frequently diagnosed cancers in women worldwide. It has surpassed lung cancer as the leading cause of cancer-related death. Breast cancer brain metastasis (BCBM) is becoming a major clinical concern that is commonly associated with ER-ve and HER2+ve subtypes of BC patients. Metastatic lesions in the brain originate when the cancer cells detach from a primary breast tumor and establish metastatic lesions and infiltrate near and distant organs via systemic blood circulation by traversing the BBB. The colonization of BC cells in the brain involves a complex interplay in the tumor microenvironment (TME), metastatic cells, and brain cells like endothelial cells, microglia, and astrocytes. BCBM is a significant cause of morbidity and mortality and presents a challenge to developing successful cancer therapy. In this review, we discuss the molecular mechanism of BCBM and novel therapeutic strategies for patients with brain metastatic BC.
540 _a
540 _ahttps://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/).
546 _aen
690 _aArticle
655 7 _aText
_2local
786 0 _nAdv Cancer Biol Metastasis
856 4 1 _uhttp://dx.doi.org/10.1016/j.adcanc.2022.100079
_zConnect to this object online.
999 _c2038
_d2038