000			02035 am a22002773u 4500
042			_adc
100	1	0	_aBenjamin, Mercilena _eauthor _91764
700	1	0	_aMalakar, Pushkar _eauthor _91765
700	1	0	_aSinha, Rohit Anthony _eauthor _91766
700	1	0	_aNasser, Mohd Wasim _eauthor _91767
700	1	0	_aBatra, Surinder K. _eauthor _91768
700	1	0	_aSiddiqui, Jawed Akhtar _eauthor _91769
700	1	0	_aChakravarti, Bandana _eauthor _91770
245	0	0	_aMolecular signaling network and therapeutic developments in breast cancer brain metastasis
260			_c2023-07.
500			_a/pmc/articles/PMC7613958/
500			_a/pubmed/36536947
520			_aBreast cancer (BC) is one of the most frequently diagnosed cancers in women worldwide. It has surpassed lung cancer as the leading cause of cancer-related death. Breast cancer brain metastasis (BCBM) is becoming a major clinical concern that is commonly associated with ER-ve and HER2+ve subtypes of BC patients. Metastatic lesions in the brain originate when the cancer cells detach from a primary breast tumor and establish metastatic lesions and infiltrate near and distant organs via systemic blood circulation by traversing the BBB. The colonization of BC cells in the brain involves a complex interplay in the tumor microenvironment (TME), metastatic cells, and brain cells like endothelial cells, microglia, and astrocytes. BCBM is a significant cause of morbidity and mortality and presents a challenge to developing successful cancer therapy. In this review, we discuss the molecular mechanism of BCBM and novel therapeutic strategies for patients with brain metastatic BC.
540			_a
540			_ahttps://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/).
546			_aen
690			_aArticle
655	7		_aText _2local
786	0		_nAdv Cancer Biol Metastasis
856	4	1	_uhttp://dx.doi.org/10.1016/j.adcanc.2022.100079 _zConnect to this object online.
999			_c2038 _d2038