000			03157 am a22003013u 4500
042			_adc
100	1	0	_aAnderson, Collene E. _eauthor _92239
700	1	0	_aBirkhäuser, Veronika _eauthor _92240
700	1	0	_aLiechti, Martina D. _eauthor _92241
700	1	0	_aJordan, Xavier _eauthor _92242
700	1	0	_aLuca, Eugenia _eauthor _92243
700	1	0	_aMöhr, Sandra _eauthor _92244
700	1	0	_aPannek, Jürgen _eauthor _92245
700	1	0	_aKessler, Thomas M. _eauthor _92246
700	1	0	_aBrinkhof, Martin W.G. _eauthor _92247
245	0	0	_aSex differences in urological management during spinal cord injury rehabilitation: Results from a prospective multicenter longitudinal cohort study
260			_c2022-10-12.
500			_a/pmc/articles/PMC7614058/
500			_a/pubmed/36224336
520			_aSTUDY DESIGN: Prospective, multicenter, longitudinal cohort study. OBJECTIVES: To describe female-male differences in first-line urological management during spinal cord injury (SCI) rehabilitation. SETTING: Inpatient specialized post-acute SCI rehabilitation in Switzerland. METHODS: Data on bladder storage medication (antimuscarinic and beta-3 agonist) use, suprapubic catheter placement, demographic and SCI characteristics was collected within 40 days of SCI and at rehabilitation discharge from May 2013-September 2021. Prevalence and indicators of bladder storage medication and suprapubic catheter use at discharge were investigated with sex-stratified descriptive and logistic regression analyses. RESULTS: In 748 patients (219 females, 29%), bladder storage medication use at discharge had a prevalence of 24% (95% CI: 18-29%) for females and 30% (95% CI: 26-34%) for males and was indicated by cervical AIS grade A,B,C and traumatic SCI in both sexes. Thoracic AIS grade A,B,C SCI (males), and lumbar/sacral AIS grade A,B,C SCI (females) predicted higher odds of bladder storage medication use (SCI characteristic*sex interaction, p<0.01). Prevalence of suprapubic catheter use at discharge was 22% (95% CI: 17-28%) for females and 17% (95% CI: 14-20%) for males. Suprapubic catheter use was indicated by cervical AIS grade A,B,C SCI, and age >60 in both sexes. Females with thoracic grade A,B,C SCI tended to have higher odds of suprapubic catheter use (SCI characteristic*sex interaction, p=0.013). CONCLUSIONS: We identified sex differences in urological management especially in persons with AIS grade C or higher sub-cervical SCI. There is scope for well-powered, female-specific research in SCI in order to understand the underlying mechanisms and support patient-tailored management.
540			_a
540			_ahttps://www.springernature.com/gp/open-research/policies/accepted-manuscript-termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms
546			_aen
690			_aArticle
655	7		_aText _2local
786	0		_nSpinal Cord
856	4	1	_uhttp://dx.doi.org/10.1038/s41393-022-00860-4 _zConnect to this object online.
999			_c2046 _d2046