| 000 | 02533 am a22003613u 4500 | ||
|---|---|---|---|
| 042 | _adc | ||
| 100 | 1 | 0 |
_aWiest, Christoph _eauthor _92669 |
| 700 | 1 | 0 |
_aHe, Shenghong _eauthor _92670 |
| 700 | 1 | 0 |
_aDuchet, Benoit _eauthor _92671 |
| 700 | 1 | 0 |
_aPogosyan, Alek _eauthor |
| 700 | 1 | 0 |
_aBenjaber, Moaad _eauthor _92673 |
| 700 | 1 | 0 |
_aDenison, Timothy _eauthor _92674 |
| 700 | 1 | 0 |
_aHasegawa, Harutomo _eauthor _92675 |
| 700 | 1 | 0 |
_aAshkan, Keyoumars _eauthor _92676 |
| 700 | 1 | 0 |
_aBaig, Fahd _eauthor _92677 |
| 700 | 1 | 0 |
_aBertaina, Ilaria _eauthor _92678 |
| 700 | 1 | 0 |
_aMorgante, Francesca _eauthor _92679 |
| 700 | 1 | 0 |
_aPereira, Erlick A. _eauthor _92680 |
| 700 | 1 | 0 |
_aTorrecillos, Flavie _eauthor |
| 700 | 1 | 0 |
_aTan, Huiling _eauthor |
| 245 | 0 | 0 | _aEvoked Resonant Neural Activity in subthalamic local field potentials reflects basal ganglia network dynamics |
| 260 | _c2023-03. | ||
| 500 | _a/pmc/articles/PMC7614125/ | ||
| 500 | _a/pubmed/36706929 | ||
| 520 | _aEvoked resonant neural activity (ERNA) is induced by subthalamic deep brain stimulation (DBS) and was recently suggested as a marker of lead placement and contact selection in Parkinson's disease. Yet, its underlying mechanisms and how it is modulated by stimulation parameters are unclear. Here, we recorded local field potentials from 27 Parkinson's disease patients, while leads were externalised to scrutinise the ERNA. First, we show that ERNA in the time series waveform and spectrogram likely represent the same activity, which was contested before. Second, our results show that the ERNA has fast and slow dynamics during stimulation, consistent with the synaptic failure hypothesis. Third, we show that ERNA parameters are modulated by different DBS frequencies, intensities, medication states and stimulation modes (continuous DBS vs. adaptive DBS). These results suggest the ERNA might prove useful as a predictor of the best DBS frequency and lowest effective intensity in addition to contact selection. Changes with levodopa and DBS mode suggest that the ERNA may indicate the state of the cortico-basal ganglia circuit making it a putative biomarker to track clinical state in adaptive DBS. | ||
| 540 | _a | ||
| 540 | _ahttps://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license. | ||
| 546 | _aen | ||
| 690 | _aArticle | ||
| 655 | 7 |
_aText _2local |
|
| 786 | 0 | _nNeurobiol Dis | |
| 856 | 4 | 1 |
_uhttp://dx.doi.org/10.1016/j.nbd.2023.106019 _zConnect to this object online. |
| 999 |
_c2048 _d2048 |
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