000			01957 am a22002293u 4500
042			_adc
100	1	0	_aPlomin, Robert _eauthor _91819
700	1	0	_aGidziela, Agnieszka _eauthor _91820
700	1	0	_aMalanchini, Margherita _eauthor _91821
700	1	0	_avon Stumm, Sophie _eauthor _91822
245	0	0	_aGene-environment interaction using polygenic scores: Do polygenic scores for psychopathology moderate predictions from environmental risk to behavior problems?
260			_c2022-09-23.
500			_a/pmc/articles/PMC7613991/
500			_a/pubmed/36148872
520			_aThe DNA revolution has energized research on interactions between genes and environments (GxE) by creating indices of G (polygenic scores) that are powerful predictors of behavioral traits. Here, we test the extent to which polygenic scores for ADHD and neuroticism moderate associations between parent reports of their children's environmental risk (E) at ages 3 and 4 and teacher ratings of behavior problems (hyperactivity/inattention, conduct problems, emotional symptoms, and peer relationship problems) at ages 7, 9 and 12. The sampling frame included up to 6687 twins from the Twins Early Development Study (TEDS). Our analyses focused on relative effect sizes of G, E and GxE in predicting behavior problems. G, E and GxE predicted up to 2%, 2% and 0.4%, respectively, of the variance in externalizing behavior problems (hyperactivity/inattention and conduct problems) across ages 7, 9 and 12, with no clear developmental trends. G and E predictions of emotional symptoms and peer relationship problems were weaker. A quarter (12 of 48) of our tests of GxE were nominally significant (p =.05). Increasing the predictive power of G and E would enhance the search for GxE.
540			_a
546			_aen
690			_aArticle
655	7		_aText _2local
786	0		_nDev Psychopathol
856	4	1	_uhttp://dx.doi.org/10.1017/S0954579422000931 _zConnect to this object online.
999			_c2058 _d2058