000			02035 am a22002653u 4500
042			_adc
100	1	0	_aMoro, V. _eauthor _92735
700	1	0	_aPacella, V. _eauthor _92736
700	1	0	_aScandola, M. _eauthor _92737
700	1	0	_aBesharati, S. _eauthor _92738
700	1	0	_aRossato, E. _eauthor _92739
700	1	0	_aJenkinson, P.M. _eauthor _92740
700	1	0	_aFotopoulou, A _eauthor _92741
245	0	0	_aA fronto-insular-parietal network for the sense of body ownership
260			_c2023-01-05.
500			_a/pmc/articles/PMC7614133/
500			_a/pubmed/35235644
520			_aNeuropsychological disturbances in the sense of limb ownership provide unique opportunities to study the neurocognitive basis of body ownership. Previous small sample studies that showed discrete cortical lesions cannot explain why multisensory, affective and cognitive manipulations alter disownership symptoms. We tested the novel hypothesis that disturbances in the sense of limb ownership would be associated not only with discrete cortical lesions, but also with disconnections of white-matter tracts supporting specific functional networks. We drew on an advanced lesion-analysis and Bayesian statistics approach in 49 right-hemisphere patients (23 with and 26 without limb disownership). Our results reveal that disturbances in the sense of ownership are associated with lesions in the supramarginal gyrus and disconnections of a fronto-insular-parietal network, involving the frontal-insular and frontal inferior longitudinal tracts, confirming previous disconnection hypotheses. Together with previous behavioural and neuroanatomical results, these findings lead us to propose that the sense of body ownership involves the convergence of bottom-up, multisensory integration and top-down monitoring of sensory salience based on contextual demands.
540			_a
546			_aen
690			_aArticle
655	7		_aText _2local
786	0		_nCereb Cortex
856	4	1	_uhttp://dx.doi.org/10.1093/cercor/bhac081 _zConnect to this object online.
999			_c2076 _d2076