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042 _adc
100 1 0 _aMalin-Mayor, Caroline
_eauthor
_92332
700 1 0 _aHirsch, Peter
_eauthor
_92333
700 1 0 _aGuignard, Leo
_eauthor
_92334
700 1 0 _aMcDole, Katie
_eauthor
_92335
700 1 0 _aWan, Yinan
_eauthor
_92336
700 1 0 _aLemon, William C.
_eauthor
_92337
700 1 0 _aKainmueller, Dagmar
_eauthor
_92338
700 1 0 _aKeller, Philipp J.
_eauthor
_92339
700 1 0 _aPreibisch, Stephan
_eauthor
_92340
700 1 0 _aFunke, Jan
_eauthor
_92341
245 0 0 _aAutomated reconstruction of whole-embryo cell lineages by learning from sparse annotations
260 _bNature Publishing Group US,
_c2022-09-05.
500 _a/pmc/articles/PMC7614077/
500 _a/pubmed/36065022
520 _aWe present a method to automatically identify and track nuclei in time-lapse microscopy recordings of entire developing embryos. The method combines deep learning and global optimization. On a mouse dataset, it reconstructs 75.8% of cell lineages spanning 1 h, as compared to 31.8% for the competing method. Our approach improves understanding of where and when cell fate decisions are made in developing embryos, tissues, and organs.
540 _a© The Author(s) 2022
540 _ahttps://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
546 _aen
690 _aBrief Communication
_92342
655 7 _aText
_2local
786 0 _nNat Biotechnol
856 4 1 _uhttp://dx.doi.org/10.1038/s41587-022-01427-7
_zConnect to this object online.
999 _c2085
_d2085