000 01919 am a22002293u 4500
042 _adc
100 1 0 _aMcNamara, Colin G.
_eauthor
_92355
700 1 0 _aRothwell, Max
_eauthor
_92356
700 1 0 _aSharott, Andrew
_eauthor
_92357
245 0 0 _aStable, interactive modulation of neuronal oscillations produced through brain-machine equilibrium
260 _c2022-11-08.
500 _a/pmc/articles/PMC7614081/
500 _a/pubmed/36351413
520 _aClosed-loop interaction has the potential to regulate ongoing brain activity by continuously binding an external stimulation to specific dynamics of a neural circuit. Achieving interactive modulation requires a stable brain-machine feedback loop. Here, we demonstrate that it is possible to maintain oscillatory brain activity in a desired state by delivering stimulation accurately aligned with the timing of each cycle. We develop a fast algorithm that responds on a cycle-by-cycle basis to stimulate basal ganglia nuclei at predetermined phases of successive cortical beta cycles in parkinsonian rats. Using this approach, an equilibrium emerges between the modified brain signal and feedback-dependent stimulation pattern, leading to sustained amplification or suppression of the oscillation depending on the phase targeted. Beta amplification slows movement speed by biasing the animal's mode of locomotion. Together, these findings show that highly responsive, phase-dependent stimulation can achieve a stable brain-machine interaction that leads to robust modulation of ongoing behavior.
540 _a
540 _ahttps://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license.
546 _aen
690 _aArticle
655 7 _aText
_2local
786 0 _nCell Rep
856 4 1 _uhttp://dx.doi.org/10.1016/j.celrep.2022.111616
_zConnect to this object online.
999 _c2095
_d2095