| 000 | 03779 am a22006373u 4500 | ||
|---|---|---|---|
| 042 | _adc | ||
| 100 | 1 | 0 |
_aKvedaraite, Egle _eauthor _92596 |
| 700 | 1 | 0 |
_aMilne, Paul _eauthor _92597 |
| 700 | 1 | 0 |
_aKhalilnezhad, Ahad _eauthor _92598 |
| 700 | 1 | 0 |
_aChevrier, Marion _eauthor _92599 |
| 700 | 1 | 0 |
_aSethi, Raman _eauthor _92600 |
| 700 | 1 | 0 |
_aLee, Hong Kai _eauthor _92601 |
| 700 | 1 | 0 |
_aHagey, Daniel W. _eauthor _92602 |
| 700 | 1 | 0 |
_avon Bahr Greenwood, Tatiana _eauthor _92603 |
| 700 | 1 | 0 |
_aMouratidou, Natalia _eauthor _92604 |
| 700 | 1 | 0 |
_aJädersten, Martin _eauthor _92605 |
| 700 | 1 | 0 |
_aLee, Nicole Yee Shin _eauthor _92606 |
| 700 | 1 | 0 |
_aMinnerup, Lara _eauthor _92607 |
| 700 | 1 | 0 |
_aYingrou, Tan _eauthor _92608 |
| 700 | 1 | 0 |
_aDutertre, Charles-Antoine _eauthor _92609 |
| 700 | 1 | 0 |
_aBenac, Nathan _eauthor _92610 |
| 700 | 1 | 0 |
_aHwang, You Yi _eauthor _92611 |
| 700 | 1 | 0 |
_aLum, Josephine _eauthor _92612 |
| 700 | 1 | 0 |
_aLoh, Amos Hong Pheng _eauthor _92613 |
| 700 | 1 | 0 |
_aJansson, Jessica _eauthor _92614 |
| 700 | 1 | 0 |
_aTeng, Karen Wei Weng _eauthor _92615 |
| 700 | 1 | 0 |
_aKhalilnezhad, Shabnam _eauthor _92616 |
| 700 | 1 | 0 |
_aWeili, Xu _eauthor _92617 |
| 700 | 1 | 0 |
_aResteu, Anastasia _eauthor _92618 |
| 700 | 1 | 0 |
_aLiang, Tey Hong _eauthor _92619 |
| 700 | 1 | 0 |
_aGuan, Ng Lai _eauthor _92620 |
| 700 | 1 | 0 |
_aLarbi, Anis _eauthor _92621 |
| 700 | 1 | 0 |
_aHowland, Shanshan Wu _eauthor _92622 |
| 700 | 1 | 0 |
_aArnell, Henrik _eauthor _92623 |
| 700 | 1 | 0 |
_aAndaloussi, Samir EL _eauthor _92624 |
| 700 | 1 | 0 |
_aBraier, Jorge _eauthor _92625 |
| 700 | 1 | 0 |
_aRassidakis, Georgios _eauthor _92626 |
| 700 | 1 | 0 |
_aGalluzzo, Laura _eauthor _92627 |
| 700 | 1 | 0 |
_aDzionek, Andrzej _eauthor _92628 |
| 700 | 1 | 0 |
_aHenter, Jan-Inge _eauthor _92629 |
| 700 | 1 | 0 |
_aChen, Jinmiao _eauthor _92630 |
| 700 | 1 | 0 |
_aCollin, Matthew _eauthor _92631 |
| 700 | 1 | 0 |
_aGinhoux, Florent _eauthor _92632 |
| 245 | 0 | 0 | _aNOTCH dependent cooperativity between myeloid lineages promotes Langerhans cell histiocytosis pathology |
| 260 | _c2022-12-23. | ||
| 500 | _a/pmc/articles/PMC7614120/ | ||
| 500 | _a/pubmed/36525505 | ||
| 520 | _aLangerhans cell histiocytosis (LCH) is a potentially fatal neoplasm, characterized by the aberrant differentiation of mononuclear phagocytes, driven by mitogen-activated protein kinase pathway activation. LCH cells may trigger destructive pathology yet remain in precarious state, finely balanced between apoptosis and survival, supported by a unique inflammatory milieu. The interactions that maintain this state are not well-known and may offer targets for intervention. Here, we used single-cell RNA-seq and protein analysis to dissect LCH lesions, assessing LCH cell heterogeneity, and comparing LCH cells with normal MNPs within lesions. We found LCH-discriminatory signatures pointing to senescence and escape from tumor immune surveillance. We also uncovered two major lineages of LCH with DC2- and DC3/Monocyte-like phenotypes and validated them in multiple pathological tissue sites by high-content imaging. Receptor-ligand analyses and lineage tracing in vitro revealed Notch dependent cooperativity between DC2 and DC3/monocyte lineages, during expression of the pathognomonic LCH program. Our results present a convergent dual origin model of LCH with MAPK pathway activation occurring prior to fate commitment to DC2 and DC3/Monocyte lineages and Notch-dependent cooperativity between lineages driving the development of LCH cells. | ||
| 540 | _a | ||
| 540 | _ahttps://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license. | ||
| 546 | _aen | ||
| 690 | _aArticle | ||
| 655 | 7 |
_aText _2local |
|
| 786 | 0 | _nSci Immunol | |
| 856 | 4 | 1 |
_uhttp://dx.doi.org/10.1126/sciimmunol.add3330 _zConnect to this object online. |
| 999 |
_c2194 _d2194 |
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