000			01919 am a22002293u 4500
042			_adc
100	1	0	_aMcNamara, Colin G. _eauthor _92355
700	1	0	_aRothwell, Max _eauthor _92356
700	1	0	_aSharott, Andrew _eauthor _92357
245	0	0	_aStable, interactive modulation of neuronal oscillations produced through brain-machine equilibrium
260			_c2022-11-08.
500			_a/pmc/articles/PMC7614081/
500			_a/pubmed/36351413
520			_aClosed-loop interaction has the potential to regulate ongoing brain activity by continuously binding an external stimulation to specific dynamics of a neural circuit. Achieving interactive modulation requires a stable brain-machine feedback loop. Here, we demonstrate that it is possible to maintain oscillatory brain activity in a desired state by delivering stimulation accurately aligned with the timing of each cycle. We develop a fast algorithm that responds on a cycle-by-cycle basis to stimulate basal ganglia nuclei at predetermined phases of successive cortical beta cycles in parkinsonian rats. Using this approach, an equilibrium emerges between the modified brain signal and feedback-dependent stimulation pattern, leading to sustained amplification or suppression of the oscillation depending on the phase targeted. Beta amplification slows movement speed by biasing the animal's mode of locomotion. Together, these findings show that highly responsive, phase-dependent stimulation can achieve a stable brain-machine interaction that leads to robust modulation of ongoing behavior.
540			_a
540			_ahttps://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license.
546			_aen
690			_aArticle
655	7		_aText _2local
786	0		_nCell Rep
856	4	1	_uhttp://dx.doi.org/10.1016/j.celrep.2022.111616 _zConnect to this object online.
999			_c2256 _d2256