000 01314 am a22002053u 4500
042 _adc
100 1 0 _aBorkakoti, Neera
_eauthor
_92812
700 1 0 _aThornton, Janet M.
_eauthor
_92813
245 0 0 _aAlphafold2 protein structure prediction : Implications for drug discovery
260 _c2023-01-06.
500 _a/pmc/articles/PMC7614146/
500 _a/pubmed/36621153
520 _aThe drug discovery process involves designing compounds to selectively interact with their targets. The majority of therapeutic targets for low molecular weight (small molecule) drugs are proteins. The outstanding accuracy with which recent artificial intelligence methods compile the three dimensional structure of proteins has made protein targets more accessible to the drug design process. Here we present our perspective of the significance of accurate protein structure prediction on various stages of the small molecule drug discovery life cycle focusing on current capabilities and assessing how further evolution of such predictive procedures can have a more decisive impact in the discovery of new medicines.
540 _a
546 _aen
690 _aArticle
655 7 _aText
_2local
786 0 _nCurr Opin Struct Biol
856 4 1 _uhttp://dx.doi.org/10.1016/j.sbi.2022.102526
_zConnect to this object online.
999 _c2264
_d2264