| 000 | 03337 am a22003613u 4500 | ||
|---|---|---|---|
| 042 | _adc | ||
| 100 | 1 | 0 |
_aKraaij, Robert _eauthor _92907 |
| 700 | 1 | 0 |
_aSchuurmans, Isabel K. _eauthor _92908 |
| 700 | 1 | 0 |
_aRadjabzadeh, Djawad _eauthor _92909 |
| 700 | 1 | 0 |
_aTiemeier, Henning _eauthor _92910 |
| 700 | 1 | 0 |
_aDinan, Timothy G. _eauthor _92911 |
| 700 | 1 | 0 |
_aUitterlinden, André G. _eauthor _92912 |
| 700 | 1 | 0 |
_aHillegers, Manon _eauthor _92913 |
| 700 | 1 | 0 |
_aJaddoe, Vincent W.V. _eauthor _92914 |
| 700 | 1 | 0 |
_aDuijts, Liesbeth _eauthor _92915 |
| 700 | 1 | 0 |
_aMoll, Henriette _eauthor _92916 |
| 700 | 1 | 0 |
_aRivadeneira, Fernando _eauthor _92917 |
| 700 | 1 | 0 |
_aMedina-Gomez, Carolina _eauthor _92918 |
| 700 | 1 | 0 |
_aJansen, Pauline W. _eauthor _92919 |
| 700 | 1 | 0 |
_aCecil, Charlotte A.M. _eauthor _92920 |
| 245 | 0 | 0 | _aThe gut microbiome and child mental health: A population-based study |
| 260 | _c2023-02-01. | ||
| 500 | _a/pmc/articles/PMC7614161/ | ||
| 500 | _a/pubmed/36494050 | ||
| 520 | _aThe link between the gut microbiome and the brain has gained increasing scientific and public interest for its potential to explain psychiatric risk. While differences in gut microbiome composition have been associated with several mental health problems, evidence to date has been largely based on animal models and human studies with modest sample sizes. In this cross-sectional study in 1,784 ten-year-old children from the multi-ethnic, population-based Generation R Study, we aimed to characterize associations of the gut microbiome with child mental health problems. Gut microbiome was assessed from stool samples using 16S rRNA sequencing. We focused on overall psychiatric symptoms as well as with specific domains of emotional and behavioral problems, assessed via the maternally rated Child Behavior Checklist. While we observed lower gut microbiome diversity in relation to higher overall and specific mental health problems, associations were not significant. Likewise, we did not identify any taxonomic feature associated with mental health problems after multiple testing correction, although suggestive findings indicated depletion of genera previously associated with psychiatric disorders, including Hungatella, Anaerotruncus and Oscillospiraceae. The identified compositional abundance differences were found to be similar across all mental health problems. Finally, we did not find significant enrichment for specific microbial functions in relation to mental health problems. In conclusion, based on the largest sample examined to date, we do not find clear evidence of associations between gut microbiome diversity, taxonomies or functions and mental health problems in the general pediatric population. In future, the use of longitudinal designs with repeated measurements of microbiome and psychiatric outcomes will be critical to identify whether and when associations between the gut microbiome and mental health emerge across development and into adulthood. | ||
| 540 | _a | ||
| 540 | _ahttps://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license. | ||
| 546 | _aen | ||
| 690 | _aArticle | ||
| 655 | 7 |
_aText _2local |
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| 786 | 0 | _nBrain Behav Immun | |
| 856 | 4 | 1 |
_uhttp://dx.doi.org/10.1016/j.bbi.2022.12.006 _zConnect to this object online. |
| 999 |
_c483 _d483 |
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