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042 | _adc | ||
700 | 1 | 0 |
_aHerrington, William G. _eauthor _92196 |
700 | 1 | 0 |
_aStaplin, Natalie _eauthor _92197 |
700 | 1 | 0 |
_aWanner, Christoph _eauthor _92198 |
700 | 1 | 0 |
_aGreen, Jennifer B. _eauthor _92199 |
700 | 1 | 0 |
_aHauske, Sibylle J. _eauthor _92200 |
700 | 1 | 0 |
_aEmberson, Jonathan R. _eauthor _92201 |
700 | 1 | 0 |
_aPreiss, David _eauthor _92202 |
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_aJudge, Parminder _eauthor _92203 |
700 | 1 | 0 |
_aMayne, Kaitlin J. _eauthor _92204 |
700 | 1 | 0 |
_aNg, Sarah Y.A. _eauthor _92205 |
700 | 1 | 0 |
_aSammons, Emily _eauthor _92206 |
700 | 1 | 0 |
_aZhu, Doreen _eauthor _92207 |
700 | 1 | 0 |
_aHill, Michael _eauthor _92208 |
700 | 1 | 0 |
_aStevens, Will _eauthor _92209 |
700 | 1 | 0 |
_aWallendszus, Karl _eauthor _92210 |
700 | 1 | 0 |
_aBrenner, Susanne _eauthor _92211 |
700 | 1 | 0 |
_aCheung, Alfred K. _eauthor _92212 |
700 | 1 | 0 |
_aLiu, Zhi-Hong _eauthor _92213 |
700 | 1 | 0 |
_aLi, Jing _eauthor _92214 |
700 | 1 | 0 |
_aHooi, Lai Seong _eauthor _92215 |
700 | 1 | 0 |
_aLiu, Wen _eauthor _92216 |
700 | 1 | 0 |
_aKadowaki, Takashi _eauthor _92217 |
700 | 1 | 0 |
_aNangaku, Masaomi _eauthor _92218 |
700 | 1 | 0 |
_aLevin, Adeera _eauthor _92219 |
700 | 1 | 0 |
_aCherney, David _eauthor _92220 |
700 | 1 | 0 |
_aMaggioni, Aldo P. _eauthor _92221 |
700 | 1 | 0 |
_aPontremoli, Roberto _eauthor _92222 |
700 | 1 | 0 |
_aDeo, Rajat _eauthor _92223 |
700 | 1 | 0 |
_aGoto, Shinya _eauthor _92224 |
700 | 1 | 0 |
_aRossello, Xavier _eauthor _92225 |
700 | 1 | 0 |
_aTuttle, Katherine R. _eauthor _92226 |
700 | 1 | 0 |
_aSteubl, Dominik _eauthor _92227 |
700 | 1 | 0 |
_aPetrini, Michaela _eauthor _92228 |
700 | 1 | 0 |
_aMassey, Dan _eauthor _92229 |
700 | 1 | 0 |
_aEilbracht, Jens _eauthor _92230 |
700 | 1 | 0 |
_aBrueckmann, Martina _eauthor _92231 |
700 | 1 | 0 |
_aLandray, Martin J. _eauthor _92232 |
700 | 1 | 0 |
_aBaigent, Colin _eauthor _92233 |
700 | 1 | 0 |
_aHaynes, Richard _eauthor _92234 |
245 | 0 | 0 | _aEmpagliflozin in Patients with Chronic Kidney Disease |
260 | _c2023-01-12. | ||
500 | _a/pmc/articles/PMC7614055/ | ||
500 | _a/pubmed/36331190 | ||
520 | _aBACKGROUND: This study, the EMPA-KIDNEY trial, was designed to assess the effects of empagliflozin in a broad range of patients with chronic kidney disease (CKD) at risk of progression. METHODS: We randomly assigned 6609 participants to empagliflozin (10mg once daily) versus matching placebo. Eligibility required an estimated glomerular filtration rate (eGFR) of ≥20 to <45 ml/minute/1.73m(2); or ≥45 to <90 ml/minute/1.73m(2) with a urinary albumin-to-creatinine ratio (ACR) of ≥200 mg/g. The primary outcome was a composite of kidney disease progression (end-stage kidney disease, a sustained eGFR <10 ml/minute/1.73m(2), a sustained decline in eGFR of ≥40%, or a renal death) or death from cardiovascular causes. RESULTS: During a median of 2.0 years follow-up, a primary outcome event occurred in 432 of 3304 patients (13.1%) in the empagliflozin group and in 558 of 3305 patients (16.9%) in the placebo group (hazard ratio, 0.72; 95% CI 0.64 to 0.82; P<0.001), with consistent results in those with or without diabetes and across the range of eGFR studied. There were fewer hospitalizations from any cause in the empagliflozin group (0.86; 0.78 to 0.95, P=0.003), but no statistically significant effect on hospitalization for heart failure or cardiovascular death (4.0% vs 4.6%), or death from any cause (4.5% vs 5.1%). The rates of serious adverse events were broadly similar in the two groups. CONCLUSIONS: Empagliflozin reduced the risk of the composite outcome of kidney disease progression or cardiovascular death in a wide range of patients at risk of CKD progression. (Funding:Boehringer Ingelheim, Eli Lilly and others; Clinicaltrials.gov:NCT03594110, EuDRACT: 2017-002971-24). | ||
540 | _a | ||
540 | _ahttps://creativecommons.org/licenses/by-nd/4.0/This work is licensed under a CC BY-ND 4.0 (https://creativecommons.org/licenses/by-nd/4.0/) International license. | ||
546 | _aen | ||
690 | _aArticle | ||
655 | 7 |
_aText _2local |
|
786 | 0 | _nN Engl J Med | |
856 | 4 | 1 |
_uhttp://dx.doi.org/10.1056/NEJMoa2204233 _zConnect to this object online. |
999 |
_c887 _d887 |