000			01499 am a22002533u 4500
042			_adc
100	1	0	_aKhodabukus, Alastair _eauthor _92269
700	1	0	_aGuyer, Tyler _eauthor _92270
700	1	0	_aMoore, Axel C. _eauthor _92271
700	1	0	_aStevens, Molly M. _eauthor
700	1	0	_aGuldberg, Robert E. _eauthor _92273
700	1	0	_aBursac, Nenad _eauthor _92274
245	0	0	_aTranslating musculoskeletal bioengineering into tissue regeneration therapies
260			_c2022-10-12.
500			_a/pmc/articles/PMC7614064/
500			_a/pubmed/36223445
520			_aMusculoskeletal injuries and disorders are the leading cause of physical disability worldwide and a considerable socioeconomic burden. The lack of effective therapies has driven the development of novel bioengineering approaches that have recently started to gain clinical approvals. In this review, we first discuss the self-repair capacity of the musculoskeletal tissues and describe causes of musculoskeletal dysfunction. We then review the development of novel biomaterial, immunomodulatory, cellular, and gene therapies to treat musculoskeletal disorders. Lastly, we consider the recent regulatory changes and future areas of technological progress that can accelerate translation of these therapies to clinical practice.
540			_a
546			_aen
690			_aArticle
655	7		_aText _2local
786	0		_nSci Transl Med
856	4	1	_uhttp://dx.doi.org/10.1126/scitranslmed.abn9074 _zConnect to this object online.
999			_c894 _d894