| 000 | 02865 am a22003733u 4500 | ||
|---|---|---|---|
| 042 | _adc | ||
| 100 | 1 | 0 |
_aRodriguez-Rodriguez, Noe _eauthor |
| 700 | 1 | 0 |
_aClark, Paula A. _eauthor _91961 |
| 700 | 1 | 0 |
_aGogoi, Mayuri _eauthor |
| 700 | 1 | 0 |
_aFerreira, Ana C. F. _eauthor _91959 |
| 700 | 1 | 0 |
_aKerscher, Bernhard _eauthor _92445 |
| 700 | 1 | 0 |
_aCrisp, Alastair _eauthor _91964 |
| 700 | 1 | 0 |
_aJolin, Helen E. _eauthor _91965 |
| 700 | 1 | 0 |
_aMurphy, Jane E. _eauthor _92446 |
| 700 | 1 | 0 |
_aSivasubramaniam, Meera _eauthor _91962 |
| 700 | 1 | 0 |
_aPedro, Luisa _eauthor _92447 |
| 700 | 1 | 0 |
_aWalker, Jennifer A. _eauthor _92448 |
| 700 | 1 | 0 |
_aHeycock, Morgan W. D. _eauthor _91963 |
| 700 | 1 | 0 |
_aShields, Jacqueline D. _eauthor _92449 |
| 700 | 1 | 0 |
_aBarlow, Jillian L. _eauthor _92450 |
| 700 | 1 | 0 |
_aMcKenzie, Andrew N. J. _eauthor _91968 |
| 245 | 0 | 0 | _aIdentification of aceNKPs, a committed common progenitor population of the ILC1 and NK cell continuum |
| 260 |
_bNational Academy of Sciences, _c2022-11-29. |
||
| 500 | _a/pmc/articles/PMC7614094/ | ||
| 500 | _a/pubmed/36442116 | ||
| 520 | _aThe development of innate lymphoid cell (ILC) transcription factor reporter mice has shown a previously unexpected complexity in ILC hematopoiesis. Using novel polychromic mice to achieve higher phenotypic resolution, we have characterized bone marrow progenitors that are committed to the group 1 ILC lineage. These common ILC1/NK cell progenitors (ILC1/NKP), which we call "aceNKPs", are defined as lineage(-)Id2(+)IL-7Rα(+)CD25(-)α4β7(-)NKG2A/C/E(+)Bcl11b(-). In vitro, aceNKPs differentiate into group 1 ILCs, including NK-like cells that express Eomes without the requirement for IL-15, and produce IFN-γ and perforin upon IL-15 stimulation. Following reconstitution of Rag2(-/-)Il2rg(-/-) hosts, aceNKPs give rise to a spectrum of mature ILC1/NK cells (regardless of their tissue location) that cannot be clearly segregated into the traditional ILC1 and NK subsets, suggesting that group 1 ILCs constitute a dynamic continuum of ILCs that can develop from a common progenitor. In addition, aceNKP-derived ILC1/NK cells effectively ameliorate tumor burden in a model of lung metastasis, where they acquired a cytotoxic NK cell phenotype. Our results identify the primary ILC1/NK progenitor that lacks ILC2 or ILC3 potential and is strictly committed to ILC1/NK cell production irrespective of tissue homing. | ||
| 540 | _aCopyright © 2022 the Author(s). Published by PNAS. | ||
| 540 | _ahttps://creativecommons.org/licenses/by/4.0/This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . | ||
| 546 | _aen | ||
| 690 | _aBiological Sciences | ||
| 655 | 7 |
_aText _2local |
|
| 786 | 0 | _nProc Natl Acad Sci U S A | |
| 856 | 4 | 1 |
_uhttp://dx.doi.org/10.1073/pnas.2203454119 _zConnect to this object online. |
| 999 |
_c917 _d917 |
||