000 | 02108 am a22003013u 4500 | ||
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042 | _adc | ||
100 | 1 | 0 |
_aFiedler, Marc _eauthor _92461 |
700 | 1 | 0 |
_aFranco-Echevarría, Elsa _eauthor _92462 |
700 | 1 | 0 |
_aSchulten, Anna _eauthor _92463 |
700 | 1 | 0 |
_aNielsen, Mathias _eauthor _92464 |
700 | 1 | 0 |
_aRutherford, Trevor J. _eauthor _92465 |
700 | 1 | 0 |
_aYeates, Anna _eauthor _92466 |
700 | 1 | 0 |
_aAhsan, Bilal _eauthor _92467 |
700 | 1 | 0 |
_aDean, Caroline _eauthor _92468 |
700 | 1 | 0 |
_aBienz, Mariann _eauthor _92469 |
245 | 0 | 0 | _aHead-to-tail polymerization by VEL proteins underpins cold-induced Polycomb silencing in flowering control |
260 |
_bCell Press, _c2022-11-08. |
||
500 | _a/pmc/articles/PMC7614096/ | ||
500 | _a/pubmed/36351412 | ||
520 | _aTranscriptional silencing through the Polycomb silencing machinery utilizes a "read-write" mechanism involving histone tail modifications. However, nucleation of silencing and long-term stable transmission of the silenced state also requires P-olycomb Repressive Complex 2 (PRC2) accessory proteins, whose molecular role is poorly understood. The Arabidopsis VEL proteins are accessory proteins that interact with PRC2 to nucleate and propagate silencing at the FLOWERING LOCUS C (FLC) locus, enabling early flowering in spring. Here, we report that VEL proteins contain a domain related to an atypical four-helix bundle that engages in spontaneous concentration-dependent head-to-tail polymerization to assemble dynamic biomolecular condensates. Mutations blocking polymerization of this VEL domain prevent Polycomb silencing at FLC. Plant VEL proteins thus facilitate assembly of dynamic multivalent Polycomb complexes required for inheritance of the silenced state. | ||
540 | _aCrown Copyright © 2022. | ||
540 | _ahttps://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | ||
546 | _aen | ||
690 | _aArticle | ||
655 | 7 |
_aText _2local |
|
786 | 0 | _nCell Rep | |
856 | 4 | 1 |
_uhttp://dx.doi.org/10.1016/j.celrep.2022.111607 _zConnect to this object online. |
999 |
_c919 _d919 |