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042 _adc
100 1 0 _aCurtis, Elizabeth M
_eauthor
700 1 0 _aFuggle, Nicholas R
_eauthor
_92542
700 1 0 _aCooper, Cyrus
_eauthor
700 1 0 _aHarvey, Nicholas C
_eauthor
245 0 0 _aBest Practice Research Clinical Endocrinology and Metabolism Epigenetic Regulation of Bone Mass
260 _c2022-03-01.
500 _a/pmc/articles/PMC7614112/
500 _a/pubmed/35120798
520 _aOsteoporosis, characterised by low bone mass, poor bone structure, and an increased risk of fracture, is a major public health problem. There is increasing evidence that the influence of the environment on gene expression, through epigenetic processes, contributes to variation in BMD and fracture risk across the lifecourse. Such epigenetic processes include DNA methylation, histone and chromatin modifications and non-coding RNAs. Examples of associations with phenotype include DNA methylation in utero linked to maternal vitamin D status, and to methylation of target genes such as OPG and RANKL being associated with osteoporosis in later life. Epigenome-wide association studies and multi-omics technologies have further revealed susceptibility loci, and histone acetyltransferases, deacetylases and methylases are being considered as therapeutic targets. This review encompasses recent advances in our understanding of epigenetic mechanisms in the regulation of bone mass and osteoporosis development, and outlines possible diagnostic and prognostic biomarker applications.
540 _a
546 _aen
690 _aArticle
655 7 _aText
_2local
786 0 _nBest Pract Res Clin Endocrinol Metab
856 4 1 _uhttp://dx.doi.org/10.1016/j.beem.2021.101612
_zConnect to this object online.
999 _c932
_d932