| 000 | 03638 am a22004453u 4500 | ||
|---|---|---|---|
| 042 | _adc | ||
| 100 | 1 | 0 |
_aMullins, Kristin _eauthor _92695 |
| 700 | 1 | 0 |
_aCanal, Enrique _eauthor _92696 |
| 700 | 1 | 0 |
_aOuch, Pidor _eauthor _92697 |
| 700 | 1 | 0 |
_aPrasetyo, Didot _eauthor _92698 |
| 700 | 1 | 0 |
_aTagoe, Janice _eauthor _92699 |
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_aAttram, Naiki _eauthor _92700 |
| 700 | 1 | 0 |
_aYeboah, Clara _eauthor _92701 |
| 700 | 1 | 0 |
_aKumordjie, Selassi _eauthor _92702 |
| 700 | 1 | 0 |
_aFox, Anne _eauthor _92703 |
| 700 | 1 | 0 |
_aLetizia, Andrew G. _eauthor _92704 |
| 700 | 1 | 0 |
_aRachlin, Audrey _eauthor _92705 |
| 700 | 1 | 0 |
_aNguyen, Hung Manh _eauthor _92706 |
| 700 | 1 | 0 |
_aRobinson, Matthew T. _eauthor _92707 |
| 700 | 1 | 0 |
_aVongsouvath, Manivanh _eauthor _92708 |
| 700 | 1 | 0 |
_aDavong, Viengmon _eauthor _92709 |
| 700 | 1 | 0 |
_aMayxay, Mayfong _eauthor _92710 |
| 700 | 1 | 0 |
_aSimons, Mark P. _eauthor _92711 |
| 700 | 1 | 0 |
_aCaranci, Angela _eauthor _92712 |
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_aNewton, Paul N. _eauthor _92713 |
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_aRichards, Allen L. _eauthor _92714 |
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_aFarris, Christina M. _eauthor _92715 |
| 245 | 0 | 0 | _aBartonella species in Cambodia, Ghana, Laos, and Peru: results from vector and sero-surveys |
| 260 | _c2023-01-01. | ||
| 500 | _a/pmc/articles/PMC7614129/ | ||
| 500 | _a/pubmed/36633562 | ||
| 520 | _aBartonella species are fastidious Gram negative vector-borne bacteria with a wide range of mammalian reservoirs. While it is understood that some species Bartonella are human pathogens, the extent of human exposure to Bartonella species (both pathogenic and non-pathogenic) has yet to be fully understood. To this end, residual sera from participants enrolled in undifferentiated fever studies in Cambodia, Ghana, Laos, and Peru were screened for the presence of IgG antibodies against B. quintana and B. henselae, using the FOCUS diagnostics Dual Spot- Bartonella IgG Immunofluorescence assay. Forty-eight patients with suspected or confirmed B. bacilliformis exposure or infection in Peru, were screened to assess cross-reactivity of the FOCUS assay for IgG against other Bartonella species. Ten of 13 patients with confirmed B. bacilliformis infection were Bartonella-specific IgG positive and overall, 36/48 of the samples were positive. Additionally, 79/206, 44/200, 101/180, and 57/100 of samples from Peru, Laos, Cambodia, and Ghana, respectively were Bartonella-specific IgG positive. Further, ectoparasites pools from Cambodia, Laos, and Peru were tested using quantitative real-time PCR (qPCR) for the presence of Bartonella DNA. Of the sand-fly pools collected in Peru, 0/196 were qPCR positive; 15/140 flea pools collected in Cambodia were qPCR positive; while 0/105 ticks, 0/22 fleas, and 0/3 louse pools collected in Laos tested positive for Bartonella DNA. Evidence of Bartonella in fleas from Cambodia supports the possibility that humans are exposed to Bartonella through this traditional vector. However, Bartonella species were not found in fleas, ticks, or lice from Laos, or sandflies from Peru. This could account for the lower positive serology among the population in Laos and the strictly localized nature of B. bacillformis infections in Peru. Human exposure to Bartonella species and Bartonella as a human pathogen warrants further investigation. | ||
| 540 | _a | ||
| 540 | _ahttps://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license. | ||
| 546 | _aen | ||
| 690 | _aArticle | ||
| 655 | 7 |
_aText _2local |
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| 786 | 0 | _nVector Borne Zoonotic Dis | |
| 856 | 4 | 1 |
_uhttp://dx.doi.org/10.1089/vbz.2021.0090 _zConnect to this object online. |
| 999 |
_c948 _d948 |
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