000 02033 am a22002653u 4500
042 _adc
100 1 0 _aMoro, V.
_eauthor
_92735
700 1 0 _aPacella, V.
_eauthor
_92736
700 1 0 _aScandola, M.
_eauthor
_92737
700 1 0 _aBesharati, S.
_eauthor
_92738
700 1 0 _aRossato, E.
_eauthor
_92739
700 1 0 _aJenkinson, P.M.
_eauthor
_92740
700 1 0 _aFotopoulou, A
_eauthor
_92741
245 0 0 _aA fronto-insular-parietal network for the sense of body ownership
260 _c2023-01-05.
500 _a/pmc/articles/PMC7614133/
500 _a/pubmed/35235644
520 _aNeuropsychological disturbances in the sense of limb ownership provide unique opportunities to study the neurocognitive basis of body ownership. Previous small sample studies that showed discrete cortical lesions cannot explain why multisensory, affective and cognitive manipulations alter disownership symptoms. We tested the novel hypothesis that disturbances in the sense of limb ownership would be associated not only with discrete cortical lesions, but also with disconnections of white-matter tracts supporting specific functional networks. We drew on an advanced lesion-analysis and Bayesian statistics approach in 49 right-hemisphere patients (23 with and 26 without limb disownership). Our results reveal that disturbances in the sense of ownership are associated with lesions in the supramarginal gyrus and disconnections of a fronto-insular-parietal network, involving the frontal-insular and frontal inferior longitudinal tracts, confirming previous disconnection hypotheses. Together with previous behavioural and neuroanatomical results, these findings lead us to propose that the sense of body ownership involves the convergence of bottom-up, multisensory integration and top-down monitoring of sensory salience based on contextual demands.
540 _a
546 _aen
690 _aArticle
655 7 _aText
_2local
786 0 _nCereb Cortex
856 4 1 _uhttp://dx.doi.org/10.1093/cercor/bhac081
_zConnect to this object online.
999 _c952
_d952