| 000 | 01638 am a22002653u 4500 | ||
|---|---|---|---|
| 042 | _adc | ||
| 100 | 1 | 0 |
_aZürcher, Jérôme F. _eauthor _92826 |
| 700 | 1 | 0 |
_aRobertson, Wesley E. _eauthor _92827 |
| 700 | 1 | 0 |
_aKappes, Tomás _eauthor _92828 |
| 700 | 1 | 0 |
_aPetris, Gianluca _eauthor _92829 |
| 700 | 1 | 0 |
_aElliott, Thomas S. _eauthor _92830 |
| 700 | 1 | 0 |
_aSalmond, George P. C. _eauthor _92831 |
| 700 | 1 | 0 |
_aChin, Jason W. _eauthor _92832 |
| 245 | 0 | 0 | _aRefactored genetic codes enable bidirectional genetic isolation |
| 260 | _c2022-11-04. | ||
| 500 | _a/pmc/articles/PMC7614150/ | ||
| 500 | _a/pubmed/36264827 | ||
| 520 | _aThe near-universal genetic code defines the correspondence between codons in genes and amino acids in proteins. We refactored the structure of the genetic code in Escherichia coli and created orthogonal genetic codes that restrict the escape of synthetic genetic information into natural life. We developed orthogonal and mutually orthogonal horizontal gene transfer systems, which permit the transfer of genetic information between organisms that use the same genetic code but restrict the transfer of genetic information between organisms that use different genetic codes. Moreover, we showed that locking refactored codes into synthetic organisms completely blocks invasion by mobile genetic elements, which carry their own translation factors and successfully invade organisms with canonical and compressed genetic codes. | ||
| 540 | _a | ||
| 546 | _aen | ||
| 690 | _aArticle | ||
| 655 | 7 |
_aText _2local |
|
| 786 | 0 | _nScience | |
| 856 | 4 | 1 |
_uhttp://dx.doi.org/10.1126/science.add8943 _zConnect to this object online. |
| 999 |
_c965 _d965 |
||