| 000 | 02401 am a22003973u 4500 | ||
|---|---|---|---|
| 042 | _adc | ||
| 100 | 1 | 0 |
_aMarin, Ines _eauthor _92841 |
| 700 | 1 | 0 |
_aBoix, Olga _eauthor _92842 |
| 700 | 1 | 0 |
_aGarcia-Garijo, Andrea _eauthor _92843 |
| 700 | 1 | 0 |
_aSirois, Isabelle _eauthor _92844 |
| 700 | 1 | 0 |
_aCaballe, Adrià _eauthor _92845 |
| 700 | 1 | 0 |
_aZarzuela, Eduardo _eauthor _92846 |
| 700 | 1 | 0 |
_aRuano, Irene _eauthor _92847 |
| 700 | 1 | 0 |
_aAttolini, Camille Stephan-Otto _eauthor _92848 |
| 700 | 1 | 0 |
_aPrats, Neus _eauthor _92849 |
| 700 | 1 | 0 |
_aLópez-Domínguez, José A _eauthor _92850 |
| 700 | 1 | 0 |
_aKovatcheva, Marta _eauthor _92851 |
| 700 | 1 | 0 |
_aGarralda, Elena _eauthor _92852 |
| 700 | 1 | 0 |
_aMuñoz, Javier _eauthor _92853 |
| 700 | 1 | 0 |
_aCaron, Etienne _eauthor _92854 |
| 700 | 1 | 0 |
_aAbad, María _eauthor _92855 |
| 700 | 1 | 0 |
_aGros, Alena _eauthor _92856 |
| 700 | 1 | 0 |
_aPietrocola, Federico _eauthor _92857 |
| 700 | 1 | 0 |
_aSerrano, Manuel _eauthor _92858 |
| 245 | 0 | 0 | _aCellular senescence is immunogenic and promotes anti-tumor immunity |
| 260 | _c2022-10-27. | ||
| 500 | _a/pmc/articles/PMC7614152/ | ||
| 500 | _a/pubmed/36302218 | ||
| 520 | _aCellular senescence is a stress response that activates innate immune cells, but little is known about its interplay with the adaptive immune system. Here, we show that senescent cells combine several features that render them highly efficient in activating dendritic cells (DCs) and antigen-specific CD8 T cells. This includes the release of alarmins, activation of interferon signaling, enhanced MHC class I machinery, and presentation of senescence-specific self-peptides that can activate CD8 T cells. In the context of cancer, immunization with senescent cancer cells elicits strong anti-tumor protection mediated by DCs and CD8 T cells. Interestingly, this protection is superior to immunization with cancer cells undergoing immunogenic cell death. Finally, the induction of senescence in human primary cancer cells also augments their ability to activate autologous antigen-specific tumor-infiltrating CD8 lymphocytes. Our study indicates that senescent cancer cells can be exploited to develop efficient and protective CD8-dependent anti-tumor immune responses. | ||
| 540 | _a | ||
| 546 | _aen | ||
| 690 | _aArticle | ||
| 655 | 7 |
_aText _2local |
|
| 786 | 0 | _nCancer Discov | |
| 856 | 4 | 1 |
_uhttp://dx.doi.org/10.1158/2159-8290.CD-22-0523 _zConnect to this object online. |
| 999 |
_c967 _d967 |
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