000			02094 am a22002773u 4500
042			_adc
100	1	0	_aGuillamón-Vivancos, Teresa _eauthor _92890
700	1	0	_aAníbal-Martínez, Mar _eauthor _92891
700	1	0	_aPuche-Aroca, Lorenzo _eauthor _92892
700	1	0	_aMoreno-Bravo, Juan Antonio _eauthor _92893
700	1	0	_aValdeolmillos, Miguel _eauthor _92894
700	1	0	_aMartini, Francisco J. _eauthor _92895
700	1	0	_aLópez-Bendito, Guillermina _eauthor _92896
245	0	0	_aInput-dependent segregation of visual and somatosensory circuits in the mouse superior colliculus
260			_c2022-08-19.
500			_a/pmc/articles/PMC7614159/
500			_a/pubmed/35981041
520			_aWhereas sensory perception relies on specialized sensory pathways, it is unclear whether these pathways originate as modality-specific circuits. We demonstrated that somatosensory and visual circuits are not by default segregated but require the earliest retinal activity to do so. In the embryo, somatosensory and visual circuits are intermingled in the superior colliculus, leading to cortical multimodal responses to whisker pad stimulation. At birth, these circuits segregate, and responses switch to unimodal. Blocking stage I retinal waves prolongs the multimodal configuration into postnatal life, with the superior colliculus retaining a mixed somato-visual molecular identity and defects arising in the spatial organization of the visual system. Hence, the superior colliculus mediates the timely segregation of sensory modalities in an input-dependent manner, channeling specific sensory cues to their appropriate sensory pathway.
540			_a
540			_ahttps://www.science.org/about/science-licenses-journal-article-reuseexclusive licensee American Association for the Advancement of Science. No claim to original US government works. https://www.science.org/about/science-licenses-journal-article-reuse
546			_aen
690			_aArticle
655	7		_aText _2local
786	0		_nScience
856	4	1	_uhttp://dx.doi.org/10.1126/science.abq2960 _zConnect to this object online.
999			_c972 _d972